Anti-N-methyl-D-aspartate receptor encephalitis coexisting with neuromyelitis optica spectrum disorders: two cases report
10.3760/cma.j.cn113694-20190929-00605
- VernacularTitle:抗N-甲基-D-天冬氨酸受体脑炎与视神经脊髓炎谱系疾病共病二例
- Author:
Xiaodong SONG
1
;
Zheng LIU
;
Dawei LI
;
Zhandong QIU
;
Jingsi WANG
;
Huiqing DONG
Author Information
1. 首都医科大学宣武医院神经内科，北京 100053
- From:
Chinese Journal of Neurology
2020;53(6):444-448
- CountryChina
- Language:Chinese
-
Abstract:
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis and neuromyelitis optica spectrum disorders (NMOSD) are central nervous system diseases mediated by autoimmune antibodies. With the improvement of diagnosis and treatment, the reports of the two diseases appearing in the same patient are increasing. To strengthen the understanding of this kind of comorbidity, two cases of anti-NMDAR-encephalitis coexisting with NMOSD admitted in our hospital were reported. The clinical manifestations and imaging examination of the two patients showed the evidence of involvement of both brain and spinal cord. The anti-NMDAR antibody and anti-aquaporin 4 antibody tests were positive. In addition, gamma globulin or corticosteroid impulse therapy was effective in the treatment of two patients.
