Advances in research on induction strategies of adult neural stem cells
10.3760/cma.j.issn.1006-7876.2020.03.011
- VernacularTitle:成体神经干细胞诱导方案研究进展
- Author:
Bingchun LIU
1
;
Jianlong YUAN
;
Ying QIU
;
Sheng YUN
Author Information
1. 内蒙古医科大学附属医院干细胞研究中心，呼和浩特 010050
- From:
Chinese Journal of Neurology
2020;53(3):217-220
- CountryChina
- Language:Chinese
-
Abstract:
For decades, researchers have focused on building genetically and phenotypically stable neural stem cell lines designed to restore the irreversible loss of function of nerve tissue to meet clinical needs. Among them, stem cells that maintain their pluripotent state in adults have also become one of the research focuses. With the development of technologies such as induced pluripotent stem cells and direct differentiation of somatic cells into desired cell types, research methods based on the use of allogeneic neural stem cells derived from embryonic or fetal neural tissue have gradually become a thing of the past. This article will review the basic molecular mechanisms surrounding the maintenance of pluripotent states of stem cells and reprogrammed somatic cells, as well as experimental protocols for inducing neural stem cells.
