Relationship between hemoglobin level and nonalcoholic fatty liver disease in male patients with primary gout
10.3760/cma.j.cn114798-20190611-00444
- VernacularTitle:男性原发性痛风患者血红蛋白水平与非酒精性脂肪肝的相关性分析
- Author:
Xiuling NIE
1
;
Linling SONG
;
Yue SU
;
Mingzhen LI
;
Junwei WANG
;
Lijin SHEN
;
Wei ZHAO
;
Lirong SUN
Author Information
1. 国家卫生健康委员会激素与发育重点实验室（天津医科大学）天津市代谢性疾病重点实验室 天津医科大学朱宪彝纪念医院（代谢病医院）内分泌研究所痛风科 300134
- From:
Chinese Journal of General Practitioners
2020;19(4):345-348
- CountryChina
- Language:Chinese
-
Abstract:
Four hundred and four male patients with primary gout were enrolled. According to the degree of nonalcoholic fatty liver diseases (NAFLD), the patients were divided into simple gout ( n=121), gout combined with mild NAFLD ( n=149) and gout combined with moderate-severe NAFLD ( n=134). The height, weight, waist, hip, blood pressure and blood biochemistry parameters of patients were measured. The degree of NAFLD was negatively correlated with the age of patients in three groups. The BMI, ratio of waist/hip, count of red cells, hemoglobin, hematocrit, red blood cell distribution width ( SD and CV), triglyceride, alanine aminotransferase and HOMA-IR were increased with the increasing of NAFLD severity (all P<0.05). Red blood cell count, hemoglobin, alanine aminotransferase, serum uric acid increased with the increasing of NAFLD severity (all P<0.05). Platelet, serum urea nitrogen and serum creatinine were decreased with the increase of NAFLD severity. Logistic regression showed that BMI, hemoglobin and HOMA-IR were independent risk factors for NAFLD. The prevalence and the severity of NAFLD was increased with increasing quadrates of hemoglobin. Taking group Q1 as a control, OR of NAFLD in group Q2 was 1.166(95 %CI:0.638-2.133), OR in group Q3 was 2.011(95 %CI:1.122-3.605)and OR in group Q4 was 3.120(95 %CI:1.613-6.034). The result indicates that hemoglobin levels are associated with the development and the severity of NAFLD in male patients with primary gout.
