One case report of aspergillus lumbar spine infection diagnosed by metagenomic next-generation sequencing after renal transplantation and literature review
10.3760/cma.j.cn421203-20200614-00189
- VernacularTitle:宏基因测序协助诊断肾移植术后曲霉菌腰椎炎一例并文献复习
- Author:
Yan QIN
1
;
Lizhi LI
;
Xiaoxiao SHAO
;
Haosen YANG
;
Yuan DONG
;
Meng JING
;
Pingping SUN
;
Haoyu CHEN
;
Hua ZHOU
;
Xiaotong WU
Author Information
1. 山西省第二人民医院肾移植透析中心，太原 030012
- From:
Chinese Journal of Organ Transplantation
2020;41(7):403-406
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the application and value of metagenomic next-generation sequencing (mNGS) in refractory infection after organ transplantation.Methods:A case report discussed about a patient with lumbar spine infection after kidney transplantation and the relevant literature was reviewed. The recipient was a 63-year-old man with low back pain after kidney transplantation. Lumbar spine magnetic resonance imaging showed lumbar spine infection. Multiple operations plus antibacterial and antituberculosis treatments were ineffective. Before and after treatment, numerous tests of traditional pathogenic microorganisms failed to detect any positive bacteria.Results:The detection of lumbar secretion by mNGS suggested aspergillus infection. The symptoms improved after dosing of voriconazole.Conclusions:The incidence of fungal infection of lumbar spine is low. The imaging manifestations are non-typical so that it is easy to misdiagnose. mNGS helps to timely diagnose and guide treatment. With a review of the literature, mNGS has some application value for some difficult and rare infectious diseases.
