Application of Mingdao immune score system for evaluating the immune status of liver transplant recipients
10.3760/cma.j.cn421203-20191110-00407
- VernacularTitle:自创免疫状态量化评分标准评估肝移植受者术后免疫状态的可行性分析
- Author:
Jiantao KOU
1
;
Xianliang LI
;
Jiqiao ZHU
;
Zixi LIU
;
Chun BAI
;
Long YANG
;
Han LI
;
Yanan JIA
;
Jun MA
;
Qiang HE
Author Information
1. 首都医科大学附属北京朝阳医院肝胆胰脾外科 北京市器官移植中心 100020
- From:
Chinese Journal of Organ Transplantation
2020;41(6):362-366
- CountryChina
- Language:Chinese
-
Abstract:
Objective:We proposed a Mingdao immune score system(MISS)to evaluate recipient's immune status after liver transplantation.Methods:From January 2017 to June 2019, retrospective analysis was conducted for 89 recipients of liver transplantation. Age/gender-matched 385 healthy controls(HC)were selected. The percentages of 30 lymphocyte subgroups of patients and HC were measured by flow cytometry. The score of each individual was calculated with our proposed MISS method. And drug concentrations and relevant clinical data were collected.Results:The normal MISS value of a healthy person was 0 score according to our criterion. In this study, the value of MISS for HC was distributed in a nearly normal fashion(-0.73±4.02). When the data from patients at different timepoints were compared, the MISS value started with -1.21±7.42 pre-operation, then declined sharply down to -8.95±8.05 at 1 month and jumped to -4.50±7.80 at 3 months. Afterward it stabilized at -4.18±7.83 between 3~12 months post-operation and finally reached -2.00±5.51 at 1 year ( P<0.05). Patients with acute rejection had higher MISS values than those without acute rejection, ( P<0.05). No significant correlation existed between blood drug concentrations and MISS values ( P>0.05). Conclusions:Our proposed MISS method may reflect the whole immune status. It is useful to manage the application of immunosuppressants in conjunctions with blood drug concentrations and liver graft function.
