Establishing kinetic models of immune cell reconstitution after allogeneic hematopoietic stem cell transplantation
10.3760/cma.j.cn421203-20190604-00248
- VernacularTitle:异基因造血干细胞移植后免疫细胞重建动力学模型的构建
- Author:
Long SU
1
;
Sujun GAO
;
Xiaoliang LIU
;
Fei SONG
;
Yehui TAN
;
Yu LIU
;
Yangzhi ZHAO
;
Jingnan SUN
;
Wei HAN
;
Yue RONG
;
Wei LI
Author Information
1. 吉林大学第一医院肿瘤中心血液科，长春 130021
- From:
Chinese Journal of Organ Transplantation
2020;41(6):351-357
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore immune cell reconstitution after allogeneic hematopoietic stem cell transplantation(allo-HSCT)by using mathematical function models.Methods:From June 2011 to May 2015, 65 patients with malignant hematological disorders were retrospectively analyzed. Immune cell frequencies and absolute counts were detected at day 14/28/42 and month 2/3/6/9/12/18/24 post-allo-HSCT. The immune cells included CD3 + T, CD4 + helper T, CD8 + effector T, regulatory T, CD19 + B, CD3 -CD56 + NK and CD3 + CD56 + NKT. Kinetic curve models and mathematical equations were established by utilizing curve model estimation. Results:Cubic curve models were observed for the changes of immune cell frequencies. Except for CD3 + T, CD8 + T and NK cells, the changes of absolute counts of immune cells conformed to cubic curve models. The reconstructed kinetic models of CD8 + T and NK cells after allo-HSCT were associated with relapse. Conclusions:Immune cell reconstitution after allo-HSCT conforms to certain mathematical function curve models. It may provide a new strategy for in-depth studies of immune reconstitution after allo-HSCT.
