Preliminary results of multicenter studies on ABO-incompatible kidney transplantation
- VernacularTitle:ABO血型不相容亲属活体肾移植的多中心研究
- Author:
Hongtao JIANG
1
;
Tao LI
;
Kun REN
;
Xiaohua YU
;
Yi WANG
;
Shanbin ZHANG
;
Desheng LI
;
Huiling GAN
;
Houqin LIU
;
Liang XU
;
Zhigang LUO
;
Peigen GUI
;
Xiangfang TAN
;
Bingyi SHI
;
Ming CAI
;
Xiang LI
;
Junnan XU
;
Liang XU
;
Tao LIN
;
Xianding WANG
;
Hongtao LIU
;
Lexi ZHANG
;
Jianyong WU
;
Wenhua LEI
;
Jiang QIU
;
Guodong CHEN
;
Jun LI
;
Gang HUANG
;
Chenglin WU
;
Changxi WANG
;
Lizhong CHEN
;
Zheng CHEN
;
Jiali FANG
;
Xiaoming ZHANG
;
Tongyi MEN
;
Xianduo LI
;
Chunbo MO
;
Zhen WANG
;
Xiaofeng SHI
;
Guanghui PEI
;
Jinpeng TU
;
Xiaopeng HU
;
Xiaodong ZHANG
;
Ning LI
;
Shaohua SHI
;
Hua CHEN
;
Zhenxing WANG
;
Weiguo SUI
;
Ying LI
;
Qiang YAN
;
Huaizhou CHEN
;
Liusheng LAI
;
Jinfeng LI
;
Wenjun SHANG
;
Guiwen FENG
;
Gang CHEN
;
Fanjun ZENG
;
Lan ZHU
;
Jun FANG
;
Ruiming RONG
;
Xuanchuan WANG
;
Guisheng QI
;
Qiang WANG
;
Puxun TIAN
;
Yang LI
;
Xiaohui TIAN
;
Heli XIANG
;
Xiaoming PAN
;
Xiaoming DING
;
Wujun XUE
;
Jiqiu WEN
;
Xiaosong XU
Author Information
- From: Chinese Journal of Organ Transplantation 2020;41(5):259-264
- CountryChina
- Language:Chinese
- Abstract: Objective:To summarize the patient profiles and therapeutic efficacies of ABO-incompatible living-related kidney transplantations at 19 domestic transplant centers and provide rationales for clinical application of ABOi-KT.Methods:Clinical cases of ABO-incompatible/compatible kidney transplantation (ABOi-KT/ABOc-KT) from December 2006 to December 2009 were collected. Then, statistical analyses were conducted from the aspects of tissue matching, perioperative managements, complications and survival rates of renal allograft or recipients.Results:Clinical data of 342 ABOi-KT and 779 ABOc-KT indicated that (1) no inter-group differences existed in age, body mass index (BMI), donor-recipient relationship or waiting time of pre-operative dialysis; (2) ABO blood type: blood type O recipients had the longest waiting list and transplantations from blood type A to blood type O accounted for the largest proportion; (3) HLA matching: no statistical significance existed in mismatch rate or positive rate of PRA I/II between two types of surgery; (4) CD20 should be properly used on the basis of different phrases; (5) hemorrhage was a common complication during an early postoperative period and microthrombosis appeared later; (6) no difference existed in postoperative incidence of complications or survival rate of renal allograft and recipients at 1/3/5/10 years between ABOi-KT and ABOc-KT. The acute rejection rate and serum creatinine levels of ABOi-KT recipients were comparable to those of ABOc-KT recipients within 1 year.Conclusions:ABOi-KT is both safe and effective so that it may be applied at all transplant centers as needed.
