Effect of early and late endarteritis upon clinical prognosis after renal transplantation
10.3760/cma.j.cn421203-20190325-00111
- VernacularTitle:肾移植术后早期与晚期单纯血管内膜炎对预后的影响
- Author:
Chuan LIN
1
;
Bo WANG
;
Jinwen LIN
;
Huiping WANG
;
Qin ZHOU
;
Hongfeng HUANG
;
Wenhan PENG
;
Jianyong WU
;
Rending WANG
;
Jianghua CHEN
Author Information
1. 浙江大学医学院附属第一医院肾脏病中心 浙江大学肾脏病研究所 浙江省肾脏病防治技术研究重点实验室 310003
- From:
Chinese Journal of Organ Transplantation
2020;41(4):252-256
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical prognosis of early endarteritis (within 2 weeks) and late endarteritis (after 2 weeks) after renal transplantation.Methods:A total of 81 cases with higher creatinineand receiving renal biopsy after renal transplantation were recruited from September 2001 to December 2014. They were divided into early endarteritis group (n=43) and late endarteritis group (n=38). Baseline profiles, serum creatine, glomerular filtration rate (GFR) before and after treatment, steroid resistance, reversal rate, graft loss and survival rate were analyzed for two groups.Results:Early endarteritis group showed worse serum creatine and GFR than late endarteritis group before rejection. Early endarteritis group had a higher rate of treatment with steroid plus antibody (86 %) than that of late endarteritis group (86 %vs.18.6 %, P<0.05). No significant inter-group difference existed in graft loss (23.3 % vs.10.5 %, P=0.131). The survival curve of transplanted kidney showed no significant inter-group difference insurvival time. Conclusions:The status of patients with early simple endothelitis is significantly worse than that of those with late simple endothelitis. However, after active treatments, the prognosis of patients with early simple endothelitis is not inferior to that of those with late simple endothelitis.
