Prognosis of chronic active antibody-mediated rejection in kidney transplantation
10.3760/cma.j.cn421203-20191018-00376
- VernacularTitle:肾移植受者骨密度评估及影响因素分析
- Author:
Li SUN
1
;
Zhijian HAN
;
Xiaobing JU
;
Jun TAO
;
Hao CHEN
;
Zhengkai HUANG
;
Zijie WANG
;
Shuang FEI
;
Min GU
;
Ruoyun TAN
Author Information
1. 南京医科大学第一附属医院泌尿外科肾移植中心，南京 210029
- From:
Chinese Journal of Organ Transplantation
2020;41(3):169-173
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the values of bone mineral density(BMD)of renal transplant recipients and analyze the influencing factors so as to provide rationales for preventing and treating osteoporosis after renal transplantation.Methods:A retrospective study was conducted for clinical data of 254 renal transplant recipients hospitalized from January 2017 to May 2019. The values of BMD of right femoral neck and lumbar vertebrae were detected by dual-energy X-ray absorptiometry(DEXA)and their relationships with other clinical parameters analyzed.Results:The average age was(40.5±9.8)years. Males accounted for 66.1 %, and menopausal women 5.9 %. The prevalence of osteopenia/osteoporosis of right femoral neck bone mass and lumbar vertebrae was 20.1 %, 2.8 % and 26.1 %, 3.6 % respectively. Chi-square test showed that recipients with lower BMD of femoral neck and lumbar spine were elders, menopausal women and those with longer postoperative time( P<0.05). Multivariate linear regression analysis indicated that BMD of right femoral neck was positively correlated with BMI and negatively correlated with acute rejection( P<0.05). The BMD of lumbar vertebrae was positively correlated with BMI and negatively correlated with PTH level ( P<0.05). Conclusions:There is a high prevalence of bone loss in kidney transplant recipients. Regular monitoring of BMD, active control of hyperparathyroidism, maintaining an excellent nutritional status, tapering of glucocorticoid dose and using immunosuppressants with less effect on bone metabolism may prevent osteoporosis.
