Two case reports ofrecurrent focal segmental glomurular sclerosis after renal transplantation and preliminary application of risk grade assessment of circulating permeability factor panel
10.3760/cma.j.issn.0254-1785.2020.02.004
- VernacularTitle:肾移植后FSGS复发二例报告并循环渗透因子组风险等级评估的应用
- Author:
Lian LI
1
;
Yafang TU
;
Wenliang LIAO
;
Juan WANG
;
Xiongfei WU
Author Information
1. 武汉大学人民医院肾病与透析移植中心 430060
- From:
Chinese Journal of Organ Transplantation
2020;41(2):75-78
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To summarize the diagnosis, treatment and outcome of recurrent focal segmental glomurular sclerosis(FSGS)after kidney transplantation and explore the predictive value of risk grade assessment of peripheral circulating permeability factor for recurrent FSGS.Methods:Retrospective analysis was performed for pathological history, biopsy finding before and after transplantation, blood level of FSGS biomarkers of two patients with recurrent FSGS. Then the relationship was analyzed between the risk grade assessment of peripheral circulating permeability factor and recurrent FSGS.Results:Both patients belonged to primary FSGS with >10g/24h urine protein. The recurrence of FSGS after transplantation was confirmed by renal biopsy. After plasma exchange, rituximab and Tripterygium wilfordii, 24-hour urine protein content declined, general edema subsided significantly and renal function stabilized.Conclusions:After renal transplantation, plasma exchange and rituximab can effectively alleviate the symptoms of recurrent FSGS. And assessing risk level of peripheral circulating permeability factor panel may have value in predicting the recurrent risk of FSGS