A study on resection extent for medullary thyroid carcinoma
10.3760/cma.j.cn113855-20200520-00407
- VernacularTitle:甲状腺髓样癌手术切除范围的研究
- Author:
Yafei SHI
1
;
Yingchao ZHANG
;
Youben FAN
;
Xianzhao DENG
;
Bomin GUO
;
Bo WU
;
Jie KANG
;
Jingyu YANG
Author Information
1. 济宁医学院附属医院甲状腺外科，山东省 272000
- From:
Chinese Journal of General Surgery
2020;35(11):856-861
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the relationship between surgical resection range and prognosis of medullary thyroid carcinoma.Methods:Clinical data of 39 patients with medullary thyroid carcinoma treated in Shanghai Sixth People′s Hospital from Jan 2017 to Mar 2020 were retrospectively analyzed.Results:There were 13 males and 26 females, age ranging from 26 to 72 years old. Preoperative calcitonin levels increased from 21.5 to 20 000 ng/L. Tumor stage: stage Ⅰ was 35.9%, stage Ⅱ 23.1%, stage Ⅲ 25.6%, stage Ⅳ 15.4%. The proportion of lymph node metastasis in central region was 53.8% (21/39). The proportion of lateral cervical lymph node metastasis was 43.6% (17/39), which was statistically related with the preoperative calcitonin level ≥200 ng/L. The median follow-up was 10 months, and the biochemical and anatomical cure rates were 66.7% and 33.3% respectively. Transient recurrent laryngeal nerve palsy, temporary and permanent hypothyroidism were 2.6%, 23% and 2.6%, respectively. There was no postoperative hemorrhage, infection, lymphatic leak or death.Conclusions:Bilateral total thyroidectomy, and at least ispilateral central lymph node dissection were advocated for patients with MTC. When preoperative calcitonin level ≥200 ng/L, lateral cervical lymph node dissection is advised.
