Comparisons of the efficacy and complications between urokinase and reteplase in catheter-directed thrombolysis in patients of deep venous thrombosis of the lower extremities
10.3760/cma.j.cn113855-20190515-00264
- VernacularTitle:瑞替普酶与尿激酶在导管溶栓中的疗效及并发症分析
- Author:
Ping WANG
1
;
Honglin DONG
Author Information
1. 山西医科大学第二医院血管外科，太原 030006
- From:
Chinese Journal of General Surgery
2020;35(10):806-809
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the efficacy, safety and total clinical benefit between urokinase and reteplase in catheter directed thrombolysis(CDT) of deep venous thrombosis(DVT) patients.Methods:The clinical data of 88 patients receiving IVC filter insertion and CDT in iliofemoral veins was retrospectively analyzed. Fifty-two patients received urokinase(UK), 36 received reteplase(rPA). The efficacy of thrombolysis were evaluated by thrombolytic rate , the change of limb circumferences. All the patients were followed up at the 3rd、6th and 12th month , Villalta score was used to estimate the severity of postthrombotic syndrome(PTS).Results:The thrombolytic rate in the UK group was 75.5% and 84.2% in the rPA( P<0.001); the change of limb circumferences in the UK group was 84.0%, vs. 90.0% in the rPA group( P<0.001); the Villalta score at the 3rd、6th and 12th month in the UK group were 3.03、3.63、4.57 respectively, while in the rPA group were 2.29、3.06、3.70 respectively( P<0.001) . The thrombolytic time and length of hospital stay in the rPA group is shorter than that in the UK′s. Conclusions:The thrombolytic efficacy of rPA is superior to UK. In addition, rPA can reduce the severity of PTS when compared with UK.
