Evaluation of multislices helieal CT for preoperative treatment effect and prognosis of patients with locally advanced gastric stromal tumor
10.3760/cma.j.cn113855-20200319-00220
- VernacularTitle:多层螺旋CT对局部进展期胃间质瘤患者术前治疗疗效及预后的评估价值
- Author:
Yingjie HAO
1
;
Tao ZHENG
;
Yang LIU
;
Qun ZHAO
;
Yong LI
;
Bibo TAN
;
Liqiao FAN
;
Honghai GUO
;
Ping′an DING
;
Yuan TIAN
;
Xiayu DU
;
Peigang YANG
Author Information
1. 河北医科大学第四医院外三科，石家庄 050011
- From:
Chinese Journal of General Surgery
2020;35(10):773-777
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate multislices helical CT (MSCT) on the efficacy and prognosis of preoperative treatment for locally advanced gastric stromal tumors(GIST).Methods:From Oct 2012 to Oct 2014 at the Fourth Hospital of Hebei Medical University 30 patients received MSCT before and after preoperative imatinib treatment to measure the changes of the GIST longest diameter, CT value and tumor volume of the primary lesion. The correlation of Choi score, tumor volume reduction rate and histological efficacy evaluation were analyzed. ROC curve was drew. Kaplan-Meier method was used to draw survival curves, and the overall survival rates under the new classification were calculated.Results:The median time for preoperative treatment was 8 (4 to 14) months. Postoperative pathology showed 4 cases (13%) with mild effects and 3 cases (10%) with low effects. Seventeen cases (57%) with moderate effect and 6 cases (20%) with high effect. Choi score was moderately correlated with histological efficacy evaluation ( R=0.512, P<0.05), and tumor volume reduction rate was strongly correlated with histological efficacy evaluation results ( R=0.620, P<0.05). When the tumor volume reduction rate of 45.83% was used as the effective threshold, the AUC under the ROC curve was the largest, and the sensitivity and specificity were 87.0% and 85.7%, respectively. The 5-year overall survival rate of 30 patients was 87%. According to the new volume grading standard, the 5-year survival rates of the effective group and the ineffective group were 95% and 67% ( P<0.05) , respectively . Conclusion:MSCT measurement of Choi score and tumor volume reduction rate can evaluate the efficacy of preoperative treatment in patients with locally advanced GIST, and tumor volume measurement standards also have certain value in prognosis perdiction.
