Diagnostic value of tumor markers in peritoneal lavage fluid for peritoneal metastasis of colorectal cancer
10.3760/cma.j.cn113855-20200312-00187
- VernacularTitle:腹腔灌洗液肿瘤标记物对结直肠癌腹膜转移的诊断价值
- Author:
Xin LIU
1
;
Yushi ZHOU
;
Qiwei XIE
;
Mujun YIN
;
Xiaodong YANG
;
Kewei JIANG
;
Zhiyuan ZHENG
;
Bin LIANG
;
Yingjiang YE
;
Shan WANG
Author Information
1. 北京大学人民医院胃肠外科 100044
- From:
Chinese Journal of General Surgery
2020;35(8):593-597
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine the diagnostic value of tumor markers in peritoneal lavage fluid from colorectal cancer patients for tumor peritoneal metastasis.Methods:A total of 227 colorectal cancer patients who undergoing surgical treatment were included. 300 ml of peritoneal lavage fluid was irrigated immediately upon laparotomy for traditional cytology (PLC) testing, 134 patients were tested for tumor marker of peritoneal lavage fluid (pTM). Univariate analysis was performed to determine the risk factors for peritoneal metastasis; pTM ROC curve was used to determine the best cutoff value; paired chi-square test was used to compare the difference between PLC and pTM detection.Results:The positive rate of PLC was 12.3% (28/227). Age>65, stage T3 + , lymph node metastasis, mucinous adenocarcinoma and increased serum CA125, CA19-9 are related to peritoneal metastasis; The best cutoff value of pTM for peritoneal metastasis : pCEA 17.095 ng/dl, sensitivity 58.3%, specificity 93.9%; pCA19-9 4.515 U/ml, sensitivity 83.3%, specificity 80.0%; pCA125 303.2 U/ml, sensitivity 58.3%, specificity 95.7%; pCA-724 3.01 U/ml, sensitivity 66.7%, specificity 95.7%; The best cutoff value of pTM for peritoneal micrometastasis: pCA19-9 3.43 U/ml, sensitivity 100%, specificity 72.2%. The positive rate of pCA19-9 was 29.85%, which was higher than that of PLC (χ 2=2.00, P<0.05). Conclusion:Peritoneal metastasis of colorectal cancer is related to tumor T stage, lymph node metastasis, tumor pathological type, and increased serum CA125 and CA19-9; pTM has diagnostic value for peritoneal metastasis of colorectal cancer.
