Expression of CD157 in colorectal cancer tissues and its clinical significances
10.3760/cma.j.cn113855-20200324-00236
- VernacularTitle:CD157蛋白在结直肠癌组织中的表达及其临床意义
- Author:
Chao SHEN
1
;
Yichao YAN
;
Bin LIANG
;
Yingjiang YE
;
Wenyue WANG
Author Information
1. 北京大学国际医院胃肠外科 102206
- From:
Chinese Journal of General Surgery
2020;35(7):554-557
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of CD157 and its significance in colorectal cancer.Methods:The expression of CD157 was detected in 50 cases of colorectal cancer tissues and corresponding adjacent normal colorectal tissues by immunohistochemistry. The correlation between the expression of CD157 and clinicopathological parameters and prognosis was analyzed statistically.Results:Higher expression of CD157 protein was observed in colorectal cancer than that in normal colorectal tissues (72% vs. 20%, χ 2=25.09, P<0.01). Moreover, High expression of CD157 was correlated with the tumor size (χ 2=7.368, P=0.007), TNM stage (χ 2=9.223, P=0.002), the depth of tumor infiltration (χ 2=4.158, P=0.041), distant metastasis (χ 2=5.521, P=0.019), vascular invasion (χ 2=6.307, P=0.012) and microsatellite instability (χ 2=4.778, P=0.029), but not with gender, age, histology type, location, differentiation grade, lymph node metastasis, nerve infiltration or Kras mutation (all P>0.05 respectively). Patients with low expression of CD157 had longer survival (45±4 )months than those with high expression (30±3)months (χ 2=5.234, P=0.022). Conclusions:High expression of CD157 in colorectal cancer tissue is related to poor survival of postoperative patients.
