The changes of peripheral blood T lymphocyte subsets predict the effect of neoadjuvant chemoradiotherapy in rectal cancer
10.3760/cma.j.cn113855-20191016-00600
- VernacularTitle:外周血T淋巴细胞亚群变化与直肠癌患者新辅助放化疗效果的关系
- Author:
Zhiwei ZHAI
1
;
Zhenjun WANG
;
Kunning ZHANG
;
Xiaofang ZHENG
;
Chunxiang YE
;
Jiagang HAN
Author Information
1. 首都医科大学附属北京朝阳医院普外科 100020
- From:
Chinese Journal of General Surgery
2020;35(5):397-400
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of peripheral blood T lymphocyte subsets on locally advanced rectal cancer after neoadjuvant chemoradiotherapy.Methods:108 patients were included at the Department of General Surgery of Beijing Chaoyang Hospital from Jun 2016 to Jun 2017. Peripheral blood was collected within one week before neoadjuvant therapy and one week before rectal surgery. Flow cytometry was applied to detect the CD3 + 、CD4 + 、CD8 + 、CD45RA + 、CD45RO + expression. Receiver operating characteristic (ROC) curve analysis was performed to determine the best cut-off value of the ratio of lymphocytes. A logistic regression model was obtained in multivariate analysis. Results:The values of CD3 + , CD4 + and CD8 + T lymphocytes in peripheral blood of the patients decreased compared with that before neoadjuvant treatment (all P<0.05). There was no significant decrease in the proportion of CD4 + , CD8 + , CD45RA + T and CD45RO + lymphocytes in patients′ peripheral blood (all P>0.05). The CD45RO in peripheral blood decreases during neoadjuvant therapy for locally advanced rectal cancer, and it is associated with better tumor regression( P<0.05). The best cut-off value for the ratio changes of CD45RO was 1.07. The ratio changes of CD45RO were the only significant factor for tumor regression in multivariate analysis ( P=0.005, OR=26.867, 95% CI: 1.530-471.635). Conclusion:The percentage of peripheral blood CD45RO may predict the sensitivity of neoadjuvant therapy in rectal cancer patients.
