Relationship between pathologically complete response of metastatic supraclavicular lymph nodes and the prognosis of breast cancer patients after neoadjuvant chemotherapy and surgery
10.3760/cma.j.cn113855-20190925-00567
- VernacularTitle:新辅助化疗后锁骨上淋巴结病理完全缓解和乳腺癌患者预后的关系
- Author:
Jiujun ZHU
1
;
Dechuang JIAO
;
Xuhui GUO
;
Jianghua QIAO
;
Lina WANG
;
Youzhao MA
;
Hui XIAO
;
Yue YANG
;
Zhenduo LU
;
Zhenzhen LIU
Author Information
1. 郑州大学附属肿瘤医院 河南省肿瘤医院乳腺科 450008
- From:
Chinese Journal of General Surgery
2020;35(5):366-370
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between ipsilateral metastatic supraclavicular lymph nodes(ISLN) pathologically complete response (spCR) and the prognosis in breast cancer after neoadjuvant chemotherapy(NAC) and lymphadenectomy.Methods:Clinical data of 234 breast cancer patients with ISLN at the time of diagnosis and receiving supraclavicular lymph node dissection following NAC were retrospectively analyzed.Results:All patients were female, with a median age of 52 years. The spCR rate was 52.6%. Multivariate analysis showed that the expression level of Ki67, the pathological status of breast and axillary nodes and the dissection number of supraclavicular lymph node were independent relate factors for spCR (all P<0.05). After a median follow-up of 16.6 months, the risk of recurrence and metastasis in the spCR group was 51%. It was lower than that in the non-spCR group ( HR=0.49, 95% CI 0.27-0.89, P=0.020). It was mainly manifested in hormone receptor negative patients. Supraclavicular spCR was an independent prognostic factor for DFS. Conclusions:The expression level of Ki67, pathological state of breast and axillary node and the dissection number of supraclavicular lymph node were independent related factors of spCR, which was also an independent predictor of DFS.
