Clinical characteristics and prognosis of 26 cases of combined hepatocellular carcinoma and cholangiocarcinoma
10.3760.cma.j.issn.1007-631X.2020.02.011
- VernacularTitle:26例混合型肝癌临床特点及预后分析
- Author:
Linhong WU
1
;
Pengji GAO
;
Jie GAO
;
Zhao LI
;
Jiye ZHU
;
Xisheng LENG
Author Information
1. 贵州省黔南州中医医院肝胆外科
- Keywords:
Carcinoma,hepatocellular;
Prognosis;
Survival analysis
- From:
Chinese Journal of General Surgery
2020;35(2):128-130
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical manifestations,imaging features and prognosis of mixed liver cancer.Methods The clinical and pathological data of 26 patients with combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CC) pathologically diagnosed after liver resection were retrospectively analyzed,and the relevant factors affecting the prognosis were statistically analyzed.Results Of the 26 cHCC-CC patients,19 were on background of chronic viral hepatitis,including 17 chronic viral hepatitis B and 2 chronic viral hepatitis C.There were 18 cases having AFP≥20ng/ml,9 cases were with carbohydrate antigen 199 (CA199) ≥ 37U/ml,and 5 cases with carcinoembryonic antigen (CEA) ≥5ng/ml.The 1-,3-,and 5-year postoperative survival rates were 68.8％,34.4％,and 17.4％.Multivariate analysis showed that serum CA199≥37U/ ml(x2 =5.687,P =0.019) was an independent risk factor for patients' survival.Conclusion Most cHCC-CC is found in association with chronic viral hepatitis.Serum CA199 ≥37U/ml is an independent risk factor affecting patients survival.
