Combined detection of MLNR and serum CEA in predicting preoperative distant metastasis of stage Ⅱ-Ⅲ colon cancer
10.3760/cma.j.issn.1007-631X.2020.01.006
- VernacularTitle:转移淋巴结比值与血清CEA联合检测对预测Ⅱ～Ⅲ期结肠癌术后远处转移的临床意义
- Author:
Wenfeng HAN
1
;
Shenyi WAN
;
Fengcheng DENG
;
Mancai WANG
;
Xiaodong XU
;
Youcheng ZHANG
Author Information
1. 兰州大学第二医院普外二科 730030
- Keywords:
Colon neoplasms;
Lymphatic metastasis;
Carcinoembryonic antigen;
Prognosis
- From:
Chinese Journal of General Surgery
2020;35(1):17-20
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the predictive value of metastatic lymph node ratio (MLNR) combined with preoperative serum carcinoembryonic antigen (CEA) in the detection of distant metastasis of stage Ⅱ-Ⅲ colon cancer after radical resection.Methods A retrospective study was performed on the clinical data of 325 patients with stage Ⅱ-Ⅲ colon cancer undergoing radical resection in the Second Hospital of Lanzhou University from Jan 2010 to Jan 2015.Results MLNR was correlated with the maximum diameter of tumors,the degree of differentiation of tumors,clinical TNM stage and distant metastasis (P ＜ 0.05),serum CEA was correlated with the maximum diameter of tumors,clinical TNM stage,nerve or vascular invasion and distant metastasis (P ＜ 0.05).Logistic regression analysis showed that low differentiation of tumor tissue,TNM Ⅲ stage,high MLNR and high serum CEA were independent risk factors for distant metastasis of colon cancer after radical operation.Conclusions The combined detection of MLNR and serum CEA has a good predictive value for distant metastasis with stage Ⅱ-Ⅲ colon cancer.
