Application of lipidomics in the analysis of sebum in acne patients
- VernacularTitle:脂质组学在痤疮皮脂分析中的应用
- Author:
Lu WEI
1
;
Mingfang ZHU
;
Qiang JU
Author Information
- From: Chinese Journal of Dermatology 2020;53(10):853-856
- CountryChina
- Language:Chinese
- Abstract: Acne is a chronic inflammatory dermatosis of pilosebaceous units. Increased sebum content is the precondition of acne occurrence, and changes of sebum components promote inflammatory reactions in acne. Imbalance of sebum homeostasis is one of the key factors for acne occurrence. Due to the complex composition and diverse structure of sebum, it is difficult to analyze all lipid compounds in sebum by using a single experimental method. Lipidomics can be used to qualitatively and quantitatively analyze hundreds of lipids with different properties and biological activities, which provides a potential insight into the role of sebum in the pathogenesis of acne. This review summarizes application of lipidomics in the analysis of sebum in acne patients.
