Role of melanocores in melanin transfer and degradation
10.35541/cjd.20190198
- VernacularTitle:黑素核在黑素转运与降解中的作用
- Author:
Qingwei GENG
1
;
Xiuzu SONG
Author Information
1. 杭州市第三人民医院皮肤科 310009
- From:
Chinese Journal of Dermatology
2020;53(8):658-660
- CountryChina
- Language:Chinese
-
Abstract:
Skin color is regulated by the change of melanin. Previous studies have shown that there are 4 modes of melanin transfer, including exocytosis-endocytosis, shedding-phagocytosis, cell phagocytosis and membrane fusion, and melanosomes are the main carrier for melanin transfer. Recent studies have shown that melanocores depending on the exocytosis-endocytosis pathway play an important role in melanin transfer. This review summarizes the melanocyte exocytosis and keratinocyte endocytosis processes in melanocore transfer, as well as the melanocore degradation process in keratinocytes after melanocore transfer, providing a new therapeutic direction for refractory pigmentory diseases.
