Propranolol for the treatment of infantile hemangioma
- VernacularTitle:普萘洛尔治疗婴儿血管瘤的研究进展
- Author:
Jicong JIANG
1
;
Jianming WU
;
Yu GAO
Author Information
- From: Chinese Journal of Dermatology 2020;53(7):573-576
- CountryChina
- Language:Chinese
- Abstract: Propranolol is a non-selective β-adrenoceptor blocker. Various studies have confirmed that it is safe and effective for the treatment of infantile hemangioma. The mechanism of action mainly includes: (1) pericyte-mediated hemodynamic changes and subsequent effects; (2) inhibiting proliferation of hemangioma-derived endothelial cells and stem cells by blocking cell cycle progression, inducing apoptosis of hemangioma-derived endothelial cells and differentiation of hemangioma-derived stem cells into adipocytes; (3) inhibiting the recruitment of endothelial progenitor cells; (4) reducing levels of pro-angiogenic factors, such as vascular endothelial growth factor, matrix metalloproteinase, etc.
