Application of metagenomics in research on atopic dermatitis
- VernacularTitle:宏基因组学在特应性皮炎研究中的应用进展
- Author:
Suling HE
1
;
Xin TIAN
;
Lijie CHEN
;
Junlong LI
;
Jianqin WANG
;
Yumei LIU
Author Information
- From: Chinese Journal of Dermatology 2020;53(4):311-314
- CountryChina
- Language:Chinese
- Abstract: Metagenomic analyses of humans and animals have showed that atopic dermatitis (AD) is associated with microbiome dysbiosis in the gut and skin. Decrease of microbial diversity can cause damage to skin barrier and aggravation of AD, and gut microbiome may be involved in the occurrence and development of AD through immune, metabolic and neuroendocrine pathways. This review summarizes the latest advances in the application of metagenomics in tmicrobiological research in and treatment of AD, possible mechanisms underlying microbiome-mediated pathogenesis of AD, and provides a theoretical reference for the microecological therapy of AD.
