NLRP3 inflammasomes and skin diseases
- VernacularTitle:NLRP3炎性小体与皮肤病
- Author:
Haojie LU
1
;
Xiuzu SONG
Author Information
- Keywords: Inflammasomes; Interleukin-1beta; Interleukin-18; Skin diseases; NLRP3
- From: Chinese Journal of Dermatology 2020;53(3):236-238
- CountryChina
- Language:Chinese
- Abstract: NOD-like receptor protein 3 (NLRP3) inflammasomes play an important role in innate immunity.It can induce the maturation and release of cytokines interleukin (IL)-1β and IL-18 by activating caspase-1,and participate in a variety of host immunoinflammatory responses.Once the regulation of NLRP3 inflammasomes is unbalanced,excessive IL-1β and IL-18 may be produced,triggering a series of inflammatory diseases.NLRP3 inflammasome activation plays important roles in skin diseases such as acne,psoriasis,pyoderma gangrenosum,polymyositis/dermatomyositis and bullous pemphigoid.This review summarizes research progress in NLRP3 inflammasomes in skin diseases.
