Role of mesenchymal stem cells and their exosomes in Th17/Treg-related pathogenesis of psoriasis

VernacularTitle:间充质干细胞及其外泌体与Th17/Treg对银屑病发病机制的研究进展
Author: Qixin HAN ¹ ; Xuping NIU ; Jia LIU ; Ruiqun QI ; Yan WU
Author Information

1. 中国医科大学附属第一医院皮肤科
Keywords: Psoriasis; Mesenchymal stem cells; Exosomes; Th17 cells; T-lymphocytes,regulatory
From: Chinese Journal of Dermatology 2020;53(2):151-154
CountryChina
Language:Chinese
Abstract: T helper 17 (Th17) cell/regulatory T (Treg)cell imbalance has been widely considered as one of immunopathogeneses of psoriasis.Mesenchymal stem cells (MSC) can inhibit the proliferation and differentiation of Th 17 cells,but induce the proliferation of Treg cells.Exosomes secreted by MSC are a kind of important carrier for intercellular communication and material transportation.Studies have found that exosomes from MSC and MSC have similar immunoregulatory function,which can inhibit the proliferation of Th17 cells and induce the differentiation of Treg cells.In recent years,many studies have shown that abnormalities of MSC in bone marrow and skin lesions of psoriasis patients are related to the occurrence of psoriasis,but the mechanism is still unclear.This review elaborates the role of normal MSC and their exosomes in the maintenance of Th 17/Treg balance,which provides ideas for studying how abnormalities of MSC in bone marrow and skin lesions of psoriasis patients participate in the occurrence of psoriasis.