Prevalence and clinical characteristics of obstructive sleep apnea in patients with primary hyperaldosteronism
10.3760/cma.j.cn112138-20191212-00813
- VernacularTitle:阻塞性睡眠呼吸暂停在原发性醛固酮增多症患者中患病情况及临床特征
- Author:
Mei MEI
1
;
Zhengping FENG
;
Ying SONG
;
Wenwen HE
;
Qingfeng CHENG
;
Shumin YANG
;
Jinbo HU
;
Kanran WANG
;
Zhixin XU
;
Zhipeng DU
;
Qifu LI
Author Information
1. 重庆原发性醛固酮增多症研究团队重庆医科大学附属第一医院内分泌科 400016
- From:
Chinese Journal of Internal Medicine
2020;59(11):866-871
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the proportion of obstructive sleep apnea (OSA) in primary aldosteronism (PA) in Chinese population and compare the clinical characteristics between PA patients with OSA and those without.Methods:A total of 96 patients diagnosed with PA from September 2015 to November 2018 were recruited in this study. OSA was screened by cardio-respiratory polygraphy. According to the apnea hypopnea index (AHI), the patients were divided into PA with OSA group (AHI ≥5 times) and PA without OSA group (AHI<5 times).Results:Among all patients (96), 69 (71.9%) were with OSA, among them 22 patients (22.9%) were with mild OSA, 17 patients (17.7%) were with moderate OSA and 30 patients (31.3%) were with severe OSA. Compared with the patients without OSA, the patients with OSA were elder, and had higher levels of body mass index (BMI), waist circumference (WC), hip circumference (HC), creatinine (CR) and glycosylated haemoglobin (HbA1c) ( P<0.05), but lower concentrations of plasma aldosterone (PAC), supine aldosterone renin concentration ratio(ARR) and the PAC after the diagnosis test ( P<0.05). Spearman correlation analyses showed that BMI, WC, HC, CR and HbA1c were positively correlated with AHI ( P<0.05), while high-density lipoproteincholesterol (HDL-C), supine-PAC and saline infusion test(SIT)-post PAC were negatively correlated with AHI ( P<0.05). Conclusions:The proportion of OSA in PA patients is relatively high (71.9%). Metabolic abnormalities are more common in PA patients with OSA, indicating that screening for OSA should be carried out routinely in PA patients.
