Solitary fibrous tumor with endocrine manifestations as the first symptom: Two case reports
10.3760/cma.j.cn311282-20200604-00413
- VernacularTitle:以内分泌表现为首发症状的孤立性纤维瘤两例
- Author:
Yun SHI
1
;
Kunyu LIU
;
Doudou CHEN
;
Min SHEN
;
Xuqin ZHENG
Author Information
1. 南京医科大学第一附属医院内分泌科 210029
- From:
Chinese Journal of Endocrinology and Metabolism
2020;36(11):966-969
- CountryChina
- Language:Chinese
-
Abstract:
Two cases of solitary fibrous tumor (SFT) with endocrine manifestations as the first symptom were investigated through comprehensively reviewing their medical history and clinical records. One case of recurrent giant solitary fibrous tumor of the thoracic cavity had repeated dizziness, palpitation and limb weakness for one month. The patient had hypoglycemia accompanied with significantly decreased serum insulin, and the ratio of insulin-like growth factor Ⅱ(IGF-Ⅱ) and insulin-like growth factor Ⅰ (IGF-Ⅰ) was greater than 10. Non-islet cell tumor hypoglycemia (NICTH) should be considered in the patient. Another case was found to have thyroid gland SFT and developed distant metastasis. The patient presented with hypoglycemia, hypokalemia and possible consumptive hypothyroidism. Clinicians should improve our understanding of the endocrine manifestations of the disease. SFT may occur in endocrine glands (such as thyroid), and may also present as NICTH and consumptive hypothyroidism.
