Relationship between famine exposure in early life and type 2 diabetes mellitus in adulthood
10.3760/cma.j.cn311282-20200403-00242
- VernacularTitle:生命早期经历饥荒与成年后2型糖尿病的相关性研究
- Author:
Hongyan QI
1
;
Rui DU
;
Chunyan HU
;
Yi ZHANG
;
Jie ZHANG
;
Shuangyuan WANG
;
Lin LIN
;
Mian LI
;
Min XU
;
Yu XU
;
Yuhong CHEN
;
Yufang BI
;
Weiqing WANG
;
Jieli LU
Author Information
1. 上海交通大学医学院附属瑞金医院内分泌代谢病科，上海市内分泌代谢病临床医学中心，上海市内分泌代谢病研究所 200025
- From:
Chinese Journal of Endocrinology and Metabolism
2020;36(11):905-911
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between exposure to famine in early life and later risk of type 2 diabetes in adulthood.Methods:A cluster sampling method was used to include 8 868 residents who were lived in the Jiading community of Shanghai during the Great Famine from 1959 to 1962 in China. Subjects were divided into non-exposed group, fetal exposure group, childhood exposure group, and adolescent exposure group. Logistic regression model was used to analyze the relationship between famine exposure in early life and the risk of type 2 diabetes in adulthood. Results:Famine exposure during childhood and adolescent both increased the risk of developing type 2 diabetes in adulthood in women. No significant correlation was observed in men. In subjects with less physical activity and lower education level, the risk of developing type 2 diabetes mellitus in adulthood was significantly higher in the famine-exposed group than that of non-exposed groupand the interactions were statistically significant.Conclusion:Early life famine exposure increases the risk of developing type 2 diabetes in adults, especially in women.
