Relationship between mild cognitive impairment and time in the range of blood glucose targets and time below the target range in elderly patients with type 2 diabetes by a cognitive assessment
10.3760/cma.j.cn311282-20191216-00557
- VernacularTitle:用认知评估量表测定老年2型糖尿病患者轻度认知功能障碍与血糖在目标范围内时间及低于目标范围时间的关系
- Author:
Jing SHANG
1
;
Yinghua LYU
;
Ruiping AN
;
Huijuan YUAN
Author Information
1. 河南省人民医院内分泌科，郑州 450003
- From:
Chinese Journal of Endocrinology and Metabolism
2020;36(9):789-793
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between mild cognitive impairment (MCI) and time in target range (TIR) and time below target glucose range (TBR) in elderly patients with type 2 diabetes.Methods:Ninety-five elderly patients with type 2 diabetes who were admitted to the Henan Provincial People′s Hospital from November 2017 to November 2018 were selected. Patients were assessed for cognitive function using the Montreal cognitive assessment (MoCA), and were classified into mild cognitive impairment group (MCI group) and non-mild cognitive impairment group (non-MCI group) according to the scores; all enrolled patients were scanned with a glucose monitoring system to record TIR and TBR within the first 24 hours of admission.Results:The MoCA score of the patients in the MCI group was (21.3±3.7)point, which was significantly lower than that in the non-MCI group (28.2±1.2)point, P<0.01); the TIR of the patients in the MCI group was significantly lower than that in non-MCI group [(50.6±24.5)% vs (65.8±28.7)%, P<0.01], the TBR of patients in the MCI group was significantly higher than that in the non-MCI group [(6.6±3.2)% vs (1.2±1.9)%, P<0.01]. Correlation analysis showed that MoCA score was negatively correlated with TBR ( r=-0.892, P<0.01) and positively correlated with TIR ( r=0.816, P=0.001). Multivariate linear regression analysis showed that when adjusted for diabetic duration and HbA 1C, TIR and TBR were independent risk factors for MoCA scores. Conclusion:The cognitive level of elderly patients with type 2 diabetes is closely related to TIR and TBR. At the same time, we must pay attention to TBR while increasing TIR.
