The exploration on clinical value of MRI fat quantification in patients with thyroid associated ophthalmopathy
10.3760/cma.j.cn311282-20200109-00010
- VernacularTitle:核磁共振脂肪定量对评估甲状腺相关性眼病的临床价值初探
- Author:
Xiaoting FENG
1
;
Yaosheng LUO
;
Zhangfang LI
;
Qing ZHANG
;
Chanyan WENG
;
Qiang ZHONG
;
Xiaodong ZHANG
;
Quan ZHOU
;
Jie SHEN
Author Information
1. 南方医科大学第三附属医院内分泌代谢科，广州 510634
- From:
Chinese Journal of Endocrinology and Metabolism
2020;36(8):690-695
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To quantify the fat of extraocular muscle in TAO patients with MRI fat-water separation technique.Methods:66 patients (129 eyes) with TAO were included in this study from November 2017 to July 2019. The age, gender, course of disease, disease activity and severity were collected. Fat fraction(FF) of the heaviest inflamed extraocular muscle was used as FFmax, the average FF of each orbital was recorded as FFmean. FF differences between groups of severity and activity were compared, the correlation between FF and clinical characteristics was also analyzed. Meanwhile, the changes of FF in follow-up patients before and after treatment were compared.Results:FFmean and FFmax of mild group were higher than moderate-to-severe as well as sight-threatening group. In male patients, active group′s FFmean and FFmax were lower. FF was different in groups which based on disease course ( P<0.05). Spearman correlation analysis showed a positive correlation between FF and disease course. Besides, there was a negative correlation between FF, disease activity, and disease severity ( P < 0.05). FF increased after treatment(FFmean: 34.03%±6.75% vs 32.26%±6.06%, P=0.040; FFmax: 33.43%±9.44% vs 29.04%±8.45%, P=0.006). Conclusion:MRI fat fraction can quickly and objectively quantify the fat of extraocular muscle, providing a new reference index for TAO′s disease evaluation.
