Study on the composition of ocular surface bacteria in patients with type 2 diabetes mellitus
10.3760/cma.j.cn311282-20190731-00305
- VernacularTitle:2型糖尿病患者眼表菌群的构成研究
- Author:
Limin WANG
1
;
Tian CHANG
;
Shanjun GAO
;
Hongcai SHI
;
Huijuan YUAN
Author Information
1. 河南省人民医院内分泌科、郑州大学人民医院、河南大学人民医院，郑州 450000
- From:
Chinese Journal of Endocrinology and Metabolism
2020;36(7):572-578
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the differences of ocular surface bacteria between patients with type 2 diabetes and healthy subjects, and to explore the relationship between ocular surface bacteria and type 2 diabetic keratopathy.Methods:Fifty subjects were selected and divided into type 2 diabetes group and healthy control group. Bacterial culture of conjunctival sac secretion was conducted and 16S rRNA sequencing was performed to analyze the difference in the composition of ocular surface bacteria between patients with type 2 diabetes and healthy subjects.Results:There were significant differences in the diversity of ocular surface bacteria between patients with type 2 diabetes and healthy subjects. The species of bacillus brevis and paenibacillus in type 2 diabetes group were significantly higher than those of the healthy control group, while the species of aquatic bacteria were lower.Conclusion:The differences in the composition of ocular surface bacteria may be related to type 2 diabetes mellitus.
