Association of sex hormone and sex hormone-binding globulin levels in patients with Graves′ disease
10.3760/cma.j.cn311282-20191121-00504
- VernacularTitle:Graves病患者性激素与性激素结合球蛋白水平的相关性研究
- Author:
Weiwei XU
1
;
Yuejun LIU
;
Lin ZHAO
;
Xiaomu LI
;
Yan LING
;
Hua BIAN
;
Zhiqiang LU
;
Min ZHANG
;
Xiaoying LI
Author Information
1. 复旦大学附属中山医院青浦分院内分泌科，上海 201700
- From:
Chinese Journal of Endocrinology and Metabolism
2020;36(6):479-484
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To identify the association of sex hormone and sex hormone-binding globulin (SHBG) levels in patients with Graves′ disease.Methods:Between December 2017 and July 2019, 152 patients with Graves′ disease were enrolled in the Department of Endocrinology and Metabolism of Zhongshan Hospital, Fudan University. Parameters such as height, weight, thyroid function, sex hormone, fasting blood glucose, insulin, C-peptide, glycosylated albumin, HbA 1C, and liver function were collected. The associations between SHBG and bioclinical characteristics were analyzed. Results:The glycosylated albumin level was negatively associated with SHBG in all subjects ( β=-0.308, P<0.01), while this association was not significant after the adjustment for thyroid hormones. Male patients had significantly lower SHBG level than female patients ( P<0.01). In male patients, SHBG was associated with luteinizing hormone ( r=0.465, P<0.01), estradiol ( r=0.629, P<0.01), testosterone ( r=0.786, P<0.01). While in female patients, SHBG was also associated with testosterone ( r=0.191, P<0.05). In multivariate linear regression analysis, estradiol was independently associated with SHBG ( β=0.329, P<0.01) in male subjects. Conclusion:The hypogonadism and infertility in Graves′ disease patients could partially be attributed to the association between SHBG and Graves′ disease.
