Research progress of leptin resistance mechanism
10.3760/cma.j.cn311282-20190726-00297
- VernacularTitle:瘦素抵抗相关机制的研究进展
- Author:
Qian MU
1
;
Zhiguo ZHANG
;
Yifei ZHANG
Author Information
1. 上海交通大学医学院附属瑞金医院内分泌代谢病科，上海市内分泌代谢病临床医学中心，上海市内分泌代谢病研究所 200025
- From:
Chinese Journal of Endocrinology and Metabolism
2020;36(6):515-519
- CountryChina
- Language:Chinese
-
Abstract:
With the progress of society and the improvement of living standard, the incidence of obesity is increasing. Serum leptin level increased significantly in the obese patients with hyperinsulinemia. However, the response to leptin is weakened, and then " leptin resistance" is widely concerned. Previous studies have focused on serum leptin levels and leptin receptor expression. In recent years, the mechanism of leptin resistance has been elucidated from different perspectives. This article tries to review the recent progress in the mechanism for leptin resistance, and briefly discusses the relationship between leptin resistance and insulin resistance, as well as the latest treatment measures for leptin resistance. With the development of leptin resistance research, it is believed that the increasing leptin sensitivity will be an important measure in obesity treatment.
