Study on the vitamin D level in hospitalized male type 2 diabetes patients and its relationship with sex hormones
10.3760/cma.j.cn311282-20191010-00414
- VernacularTitle:住院男性2型糖尿病患者维生素D水平及其与性激素的关系
- Author:
Tong GONG
1
;
Xue HAN
;
Guofang CHEN
;
Chao LIU
Author Information
1. 南京中医药大学附属中西医结合医院内分泌科，江苏省中医药研究院 210028
- From:
Chinese Journal of Endocrinology and Metabolism
2020;36(5):400-404
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the serum level of 25-hydroxy vitamin D[25(OH)D] in hospitalized type 2 diabetes men and determine the association between 25(OH)D and sex hormones.Methods:We performed a study among 371 male adults with type 2 diabetes in hospital. The fasting blood was collected for the measurements of 25(OH)D, glucose and lipid metabolism indexes, bone metabolism indexes and sex hormones. Patients were divided into four groups according to the quartiles of 25(OH)D. The differences of glycolipid metabolism and sex hormone indexes between groups were compared. Multivariate linear regression method was used to analyze the correlations between 25(OH)D, glucose and sex hormones.Results:Patients with vitamin D deficiency or insufficiency accounted for 96.5% of the hospitalized type 2 diabetes men. Patients with higher 25(OH)D were with higher HDL-C and lower BMI, HOMA-IR, and TG ( P<0.05). In the linear regression model, 25(OH)D had a significant correlation with TT ( β=0.116, P=0.006), and 25(OH)D had no statistically significant association with TT( β=0.061, P=0.053) after adjusting for BMI. Conclusion:In hospitalized male patients with type 2 diabetes, vitamin D is generally deficient or insufficient, and there is a positive linear correlation between 25(OH)D and testosterone, however, it is affected by BMI.
