The relationship between hyperuricemia and mild cognitive impairment in non-obese elderly
10.3760/cma.j.cn311282-20191209-00543
- VernacularTitle:高尿酸血症与非肥胖老年人轻度认知障碍的关系
- Author:
Shibin LI
1
;
Guanghui XIAO
;
Feng WANG
;
Yanhui WANG
;
Wenqin ZHANG
;
Jia GAO
Author Information
1. 天津医科大学保健医疗部 300052
- From:
Chinese Journal of Endocrinology and Metabolism
2020;36(5):405-409
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine the relationship between uric acid (UA) and mild cognitive impairment (MCI), and its potential effect on inflammation.Methods:450 patients with MCI diagnosed by neuropsychological scale and 450 controls with normal cognitive function were included. All subjects were≥60 years old. There were 184 obese subjects in MCI group and 199 obese subjects in control group.Results:A correlation between increased serum UA level and decreased risk of MCI was found in all MCI patients and non-obese MCI patients ( OR: 0.60, 95% CI 0.45-0.78; OR: 0.42, 95% CI 0.29-0.62), but not in obese MCI patients ( OR: 0.86, 95% CI: 0.54-1.35). The levels of UA and hypersensitive C reactive protein (hs-CRP) in obese patients with MCI were higher than those in non-obese patients ( P<0.01). There was a linear positive correlation between serum UA and hs-CRP levels in obese patients with MCI ( r=0.505, P<0.01), but not in non-obese MCI patients ( r=0.053, P=0.385). Conclusion:A significant correlation between lower serum uric acid levels and higher risk of MCI in non-obese subjects was found. Inflammation caused by obesity may weaken this relationship.
