The association between serum uric acid and cognitive dysfunction
10.3760/cma.j.cn311282-20191221-00567
- VernacularTitle:尿酸与认知功能障碍关系的研究进展
- Author:
Yuanyue ZHU
1
;
Yufang BI
Author Information
1. 上海交通大学医学院附属瑞金医院内分泌代谢病科，上海市内分泌代谢病研究所，上海市内分泌代谢病临床医学中心 200025
- From:
Chinese Journal of Endocrinology and Metabolism
2020;36(5):437-441
- CountryChina
- Language:Chinese
-
Abstract:
As the aging process accelerates, cognitive dysfunction has become a significant public health problem. Recently, oxidative stress has been recognized as a critical factor contributing to the pathogenesis of cognitive dysfunction. Therefore, uric acid, as an important antioxidant in vivo, might correspondingly play cognitive protection roles. However, uric acid was regarded as a risk factor for cognitive deterioration in some studies. The uric acid paradox, together with the pathophysiological differences between cognitive disorders, adds to the complexity of their association. So far, the impact of uric acid on cognitive function has been debated. This article tried to review the impact of uric acid on different cognitive disorders and to discuss the possible mechanisms.
