Association of serum liver enzymes with thyroid hormones and Chinese visceral adipose index in patients with type 2 diabetes mellitus
10.3760/cma.j.cn311282-20191025-00447
- VernacularTitle:2型糖尿病患者血清肝酶谱与甲状腺激素和中国人内脏脂肪指数的关系
- Author:
Minjie JIA
1
;
Bo FENG
Author Information
1. 同济大学附属东方医院内分泌科，上海 200120；奉浦街道社区卫生服务中心，上海 201400
- From:
Chinese Journal of Endocrinology and Metabolism
2020;36(4):326-329
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the association of serum liver enzymes with thyroid hormones and Chinese visceral adipose index (CVAI) in patients with type 2 diabetes mellitus (T2DM), and to evaluate the influencing factors of liver enzymes.Methods:A total of 700 patients with T2DM were divided into elevated liver enzyme group and normal liver enzyme group, or three groups according to tertiles in alanine aminotransferase (ALT), aspartate aminotransferase (AST), and glutamyltransferase (GGT). The differences of thyroid hormones and CVAI among groups were compared, and the correlations of liver enzyme levels with thyroid hormones and CVAI were determined.Results:Compared with the normal liver enzyme group, thyroxine(T 4)and CVAI were increased in the elevated liver enzyme group ( P<0.05). Free triiodothyroid (FT 3), triiodothyroid (T 3), and T 4 levels were elevated with the increase of ALT and AST ( P<0.05). CVAI was elevated with the increase of ALT and GGT ( P<0.05). Correlation analysis showed that FT 3, T 3, and T 4were positively correlated with ALT and AST. ALT and GGT were positively correlated with CVAI. CVAI was positively correlated with FT 3 and T 3. HbA 1Cwas negatively correlated with FT 3, T 4, and T 3. Regression analysis showed that FT 3, CVAI, and HbA 1C were the influencing factors for ALT, T 4 was the influencing factor for AST, T 3 and HbA 1Cwere the influencing factors for GGT. Conclusions:In patients with T2DM, thyroid hormones and CVAI are correlated with liver enzymes.
