Effects of different depths of anesthesia on CD4 + T cell function in patients undergoing radical resection for malignant tumor
10.3760/cma.j.cn131073.20190923.00807
- VernacularTitle:不同麻醉深度对恶性肿瘤根治术患者CD4 ＋T细胞功能的影响
- Author:
Shasha ZHAO
1
;
Yu WANG
;
Xiaohu ZHANG
;
Tao YU
;
Zhen HAO
;
Rongliang XUE
Author Information
1. 西安交通大学第二附属医院麻醉科 710004；咸阳市中心医院麻醉科 712000
- From:
Chinese Journal of Anesthesiology
2020;40(8):923-925
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effects of different depths of anesthesia on CD4 + T cell function in the patients undergoing radical resection for malignant tumor. Methods:Forty-two American Society of Anesthesiologists physical status Ⅱ patients, aged 36-64 yr, weighing 49-95 kg, undergoing elective radical surgery for malignant tumor, were divided into 2 groups ( n=21 each) using a random number table method: light anesthesia group (L group) and deep anesthesia group (D group). The AAI values were maintained at 30-40 and 20-29 during operation in L group and D group, respectively.The time to eye opening, extubation time and consumption of propofol were recorded.The peripheral venous blood samples were collected immediately before induction of anesthesia (T 0), at 2 h of operation (T 1) and at 4, 24, and 72 h after operation (T 2-4) for determination of serum interferon (IFN)-γ and interleukin-4 (IL-4) concentrations (by enzyme-linked immunosorbent assay), and IFN-γ/IL-4 ratio was calculated. Results:Compared with the baseline value at T 0, the serum IFN-γ concentrations were significantly increased at T 3, 4, the serum IL-4 concentrations were decreased at T 1-4, and IFN-γ /IL-4 ratio was increased in group D ( P<0.05). Compared with group L, the serum IFN-γ concentrations were significantly increased at T 3, 4, the serum IL-4 concentrations were decreased at T 1-4, IFN-γ/IL-4 ratio was increased, the consumption of propofol was increased, and the extubation time was prolonged in group D ( P<0.05), and no significant change was found in the time to eye opening between the two groups ( P>0.05). Conclusion:Deep anesthesia can improve CD4 + T cell function in the patients undergoing radical resection for malignant tumor.
