Relationship between TRPV1 gene polymorphism and genetic susceptibility to type 2 diabetes mellitus and intraoperative adverse cardiovascular events
10.3760/cma.j.cn131073.20191104.00510
- VernacularTitle:TRPV1基因多态性与2型糖尿病遗传易感性及术中不良心血管事件的关系
- Author:
Xiangfeng ZHAO
1
;
Wentao DENG
;
Xiaofei CHU
;
Zheng GUO
Author Information
1. 山西医科大学麻醉学系 山西医科大学第二医院麻醉科 国家教育部细胞生理学实验室，太原 030001
- From:
Chinese Journal of Anesthesiology
2020;40(5):557-560
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine the relationship between transient receptor potential vanilloid 1 (TRPV1) gene polymorphism and genetic susceptibility to type 2 diabetes mellitus (DM) and intraoperative adverse cardiovascular events (ACVEs).Methods:Eighty-six DM patients and 78 non-DM patients (nDM) undergoing elective knee replacement or posterior lumbar interbody fusion were selected in this study.Real-time fluorescence quantitative polymerase chain reaction was carried out to genotype the rs222747 variant of TRPV1 gene.The ACVEs occurred were recorded during operation, and the risk factors for ACVE developed during operation were identified.Results:Compared with nDM group, the TRPV1 genotype G/G ratio, allele G frequency, and incidence of intraoperative ACVE were significantly increased in DM group ( P<0.05). Aging and TRPV1 genotype GG combined with DM were the risk factors for intraoperative ACVEs occurred ( P<0.05). Conclusion:TRPV1 gene polymorphism is related to the genetic susceptibility to type 2 DM and occurrence of intraoperative ACVEs.
