Effect of general anesthesia on microelectrode recording during deep brain stimulation of subthalamic nucleus in patients with primary Parkinson′s disease
10.3760/cma.j.issn.0254-1416.2020.02.020
- VernacularTitle:全身麻醉对原发性帕金森病患者丘脑底核脑深部电刺激术中微电极记录的影响
- Author:
Yuting LING
1
;
Yi LIU
;
Linan ZHANG
;
Wenbiao XIAN
;
Wanru CHEN
;
Zhuning CHEN
;
Chao YANG
;
Jinlong LIU
;
Ling CHEN
;
Wenqi HUANG
;
Liangcan XIAO
;
Nan JIANG
Author Information
1. 中山大学附属第一医院麻醉科，广州 510080
- From:
Chinese Journal of Anesthesiology
2020;40(2):206-209
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of general anesthesia on microelectrode recording (MER) during deep brain stimulation (DBS) of subthalamic nucleus (STN) in the patients with primary Parkinson′s disease (PD).Methods:Forty-four patients of both sexes with primary PD (duration of disease ≥ 5 yr and/or obvious symptom fluctuation), undergoing bilateral STN DBS from March 2008 to March 2018, aged<80 yr, were selected and divided into 2 groups by a random number table method: awake group ( n=26) and general anesthesia group ( n=18). In awake group, 0.5% ropivacaine was used for incision infiltration at skin incision.Patients in GA group received propofol and remifentanil by target-controlled infusion with Narcotrend to monitor the depth of anesthesia, and 0.5% ropivacaine was used for incision infiltration at skin incision.The total number of trajectories and length of STN were recorded during MER.Movement disorders were evaluated at 1 week before surgery and 6 months after surgery, and the improvement rate of dyskinesia was calculated.The postoperative anesthesia-, hardware- and stimulation-related complications were recorded. Results:There were no significant differences between the two groups in the total number of trajectories, length of STN and improvement rate of postoperative movement disorders ( P>0.05). Conclusion:General anesthesia does not affect the MER during STN DBS in the patients with primary PD.
