Comparison of effects of doxazosin and phenoxybenzamine on intraoperative hemodynamics in patients with normotensive pheochromocytoma
10.3760/cma.j.issn.0254-1416.2020.01.009
- VernacularTitle:多沙唑嗪与酚苄明对正常血压型嗜铬细胞瘤病人术中血流动力学影响的比较
- Author:
Hao KONG
1
;
Nan LI
;
Xueying LI
Author Information
1. 北京大学第一医院麻醉与重症医学科 100034
- From:
Chinese Journal of Anesthesiology
2020;40(1):40-43
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the effects of phenoxybenzamine and doxazosin on intraoperative hemodynamics in patients with normotensive pheochromocytoma.Methods:Perioperative data of patients who underwent surgery for normotensive pheochromocytoma in Peking University First Hospital from January 1, 2004 to December 31, 2017 were collected.Patients were divided into phenoxybenzamine group and doxazosin group according to the type of preoperative α-blockade.The primary endpoint was intraoperative hemodynamic fluctuations.Secondary endpoints included postoperative circulatory support, complications, mortality, and etc.Results:Sixty-one patients were included in the study, with 24 cases in phenoxybenzamine group and 37 cases in doxazosin group.There was no significant difference in the area under the curve of intraoperative blood pressure fluctuation between the two groups ( P>0.05). The area under the curve of intraoperative heart rate >110 bpm was significantly greater in phenoxybenzamine group than in doxazosin group ( P<0.05). There was no significant difference in the secondary endpoints between the two groups ( P>0.05). Conclusion:The effect of preoperative administration of doxazosin or phenoxybenzamine on blood pressure fluctuation has no significantly statistical difference in patients with normotensive pheochromocytoma, and the patients took phenoxybenzamine preoperatively have an increased risk of intraoperative tachycardia.
