The mechanism of USP7 in prostate cancer
10.3760/cma.j.cn112330-20200130-00049
- VernacularTitle:USP7在前列腺癌发病机制中的研究
- Author:
Rusha YIN
1
;
Qiang FU
;
Keqin ZHANG
;
Hui ZHANG
;
Dingqi SUN
;
Aiyun ZHU
;
Shuai LIU
Author Information
1. 山东大学附属省立医院泌尿外科，济南 250021
- From:
Chinese Journal of Urology
2020;41(7):555-558
- CountryChina
- Language:Chinese
-
Abstract:
The traditional androgen deprivation therapy has been challenged since the appearance of castration resistant prostate cancer (CRPC). More and more researches are focusing on searching the proper molecular target to inhibit the progression of tumors. Ubiquitin specific protease 7(USP7), as an important deubiquitinating enzyme, regulates the half-life or subcellular localization of key proteins via posttranslational modification. It has been reported recently that prostate cancer cells are suppressed by USP7 inhibitors, but the complicated mechanisms remain to clarify. In this paper, we review the mechanism of USP7 in prostate cancer, suggesting the potential value of USP7 inhibitors in the treatment of CRPC.
