Research progress on the clinical application of brain-derived neurotrophic factor and its Val66Met gene polymorphism in Alzheimer's disease
10.3760/cma.j.issn.0254-9026.2020.11.024
- VernacularTitle:脑源性神经营养因子及其Val66Met基因多态性在阿尔茨海默病中的临床应用
- Author:
Lixiao HAO
1
;
Jianguo JIA
;
Zhongying ZHANG
;
Ying HAN
Author Information
1. 首都医科大学宣武医院全科医学科 100053
- From:
Chinese Journal of Geriatrics
2020;39(11):1346-1349
- CountryChina
- Language:Chinese
-
Abstract:
Increasing evidence indicates that brain-derived neurotrophic factor(BDNF), especially its BDNFVal66Met gene polymorphism, plays an important role in cognitive function of Alzheimer's disease(AD), with its effects on cognition function confirmed by a large number of studies.Therefore, this article reviews the clinical application of BDNF and BDNFVal66Met for Alzheimer's disease(AD), aiming to examine their practical value and effects on AD.
