Effects of maximal androgen blockade therapy on serum calcium, phosphorus and other metabolic indices in elderly patients with prostate cancer
10.3760/cma.j.issn.0254-9026.2020.11.020
- VernacularTitle:全雄激素阻断治疗对老年前列腺癌患者血清钙磷等代谢指标的影响
- Author:
Shicong LAI
1
;
Xuan WANG
;
Tongxiang DIAO
;
Shengjie LIU
;
Xingbo LONG
;
Zijian TIAN
;
Jianyong LIU
;
Huimin HOU
;
Jianye WANG
;
Ming LIU
Author Information
1. 北京医院泌尿外科 国家老年医学中心 中国医学科学院老年医学研究院，北京 100730；中国医学科学院北京协和医学院研究生院，北京 100730
- From:
Chinese Journal of Geriatrics
2020;39(11):1331-1334
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of maximal androgen blockade(MAB)therapy on serum calcium, phosphorus and other metabolic indices in elderly patients with prostate cancer.Methods:Clinicopathological data of prostate cancer patients treated with MAB in our department from January 2010 to December 2018 were retrospectively analyzed.All patients underwent prostate biopsy for definitive diagnosis.Detailed data on patient's age, body mass index(BMI), previous medical history, treatment plan and peripheral blood indicators before and after endocrine treatment, such as blood calcium, phosphorus, hemoglobin, fasting blood glucose, triglycerides and cholesterol, were collected.Results:Patients had a mean age of(75.5±5.8)years and a mean BMI of(24.6±3.2)kg/m 2.Blood calcium levels exhibited a downward trend after MAB treatment compared pre-treatment[(2.12±0.44)mmol/L vs.(2.17±0.31)mmol/L, t=0.82, P=0.42], but had no significant difference.Serum phosphorus concentrations were higher and the calcium-phosphorus ratio was lower after MAB treatment than before treatment[(1.02±0.26)mmol/L vs.(1.17±0.34)mmol/L, 2.10±0.28 vs.1.88±0.60, t=-4.12 and 3.56, P<0.01]. After MAB treatment, blood fasting glucose[(6.50±1.55)mmol/L vs.(5.34±1.04)mmol/L, t=-7.82, P<0.01], triglycerides[(1.66±1.32)mmol/L vs.(1.22±0.59)mmol/L, t=-3.38, P<0.01]and cholesterol[(4.70±1.08)mmol/L vs.(4.16±0.90)mmol/L, t=-4.72, P<0.01]were elevated, while hemoglobin concentrations[(122.11±20.43)g/L vs.(130.78±23.98)g/L, t=3.98, P<0.01]were decreased compared with pre-treatment levels. Conclusions:MAB therapy can cause varying degrees of metabolic abnormalities in calcium and phosphorus metabolism, hemoglobin concentrations, blood glucose and lipid levels in elderly prostate cancer patients.The above indicators should be closely monitored during treatment, and treatment-related complications should be proactively prevented.
