Measurement protocol and discriminant analysis of rapid screening tools for assessing the risk of mild cognitive impairment
10.3760/cma.j.issn.0254-9026.2020.10.010
- VernacularTitle:轻度认知障碍风险快速筛查工具的测算过程及判别效果分析
- Author:
Yiru YANG
1
;
Chenlong LYU
;
Shaokun ZHAO
;
He LI
;
Zhanjun ZHANG
Author Information
1. 北京师范大学认知神经科学与学习国家重点实验室 100875；北京师范大学老年脑健康研究中心 100875
- From:
Chinese Journal of Geriatrics
2020;39(10):1146-1150
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To develop rapid screening tools for assessing the risk of mild cognitive impairment(MCI)based on neuropsychological scales and cognitive paradigms.Methods:Two baseline datasets from the Beijing Ageing Brain Rejuvenation Initiative(BABRI)cohort were studied: dataset 1 contained 5 593 subjects, with 1 500 cases with MCI and 4 093 cases with normal cognitive function(the control group); dataset 2 consisted of 588 subjects, with 92 cases with MCI and 496 cases with normal cognitive function(the control group). Dataset 1 was used to simplify the Mini-Mental State Examination(MMSE), and the sub-item combination with the strongest MCI discriminative ability was selected to integrate into the cognitive rapid assessment(BABRI-mini MMSE). Dataset 2 with scores of encoding-recognition episodic memory task was used for further MCI discriminant analysis and was adapted into an episodic memory test(BABRI-EMT). We applied the receiver operating characteristic curve(ROC)for those analyses.Results:The control group and the MCI group showed significant differences in multi-domain cognitive ability and episodic memory task performance( P<0.01). Among sub-items of MMSE measured using dataset 1, MMSE12 and MMSE19 had the highest discriminative accuracy for MCI, and the area under the ROC(AUC)was 0.699 and 0.631, respectively.Dataset 2 was used to investigate the discriminative ability of the episodic memory score in combination with the above two MMSE sub-items for MCI, and the AUC value was 0.732, the sensitivity was 0.731, and the specificity was 0.656. Conclusions:The BABRI-mini MMSE and BABRI-EMT are suitable for the large-scale universal screening of MCI risk.
