Bidirectional regulation of senescence-associated secretory phenotype on malignant tumors
10.3760/cma.j.issn.0254-9026.2020.08.028
- VernacularTitle:衰老相关分泌表型对恶性肿瘤的双向调节作用
- Author:
Yuehui LIANG
1
;
Fang XIAO
Author Information
1. 中南大学湘雅公共卫生学院卫生毒理学系，长沙 410078
- From:
Chinese Journal of Geriatrics
2020;39(8):971-975
- CountryChina
- Language:Chinese
-
Abstract:
The senescence-associated secretory phenotype(SASP)has bidirectional regulation on tumor cells.However, a comprehensive analysis of the impact of SASP on major malignant tumors is still lacking.This article aims to review the types, characteristics and regulatory roles of SASP in several malignant tumors including liver cancer, breast cancer and prostate cancer, in order to provide a theoretical basis for the mechanisms of occurrence, development, and metastasis of these malignant tumors.
