A clinical study of vascular endothelial function in elderly people with prehypertension
10.3760/cma.j.issn.0254-9026.2020.08.006
- VernacularTitle:老年高血压前期患者血管内皮功能的临床研究
- Author:
Xiangting TIAN
1
;
Huijian YANG
;
Meng ZHENG
;
Yongchi CHEN
Author Information
1. 广东省人民医院 广东省医学科学院 广东省老年医学研究所心内科，广州 510080
- From:
Chinese Journal of Geriatrics
2020;39(8):879-882
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effect of lifestyle intervention and Irbesartan intervention on vascular endothelial function in elderly people with prehypertension.Methods:Seventy elderly people with prehypertension were randomly divided into the lifestyle intervention group and the Irbesartan intervention group.After one year of intervention, the level of cyclic endothelial microparticles(EMPs)and brachial-ankle pulse wave conduction velocity(baPWV)before and after the intervention were compared between the two groups.Results:There were significant differences in levels of circulating EMPs[(1 946±234)/μl vs.(1 745±416)/μl, t=2.530, P=0.011]and baPWV[(1 653±172)cm/s vs.(1 511±230)cm/s, t=2.448, P=0.017]before and after one year of lifestyle intervention.There were also significant differences in levels of circulating EMPs[(19 507±146)/μl vs.(1 446±286)/μl, t=3.340, P=0.002]and baPWV[(1 639±165)cm/s vs.(1 361±211)cm/s, t=3.156, P=0.005]before and after one year of Irbesartan intervention and between the lifestyle intervention group and the Irbesartan intervention group after one year( t=2.238 and 2.475, P<0.05). Conclusions:Lifestyle intervention and Irbesartan intervention have protective effects on vascular endothelial function and delay the initiation and progression of atherosclerosis in elderly people with prehypertension, and irbesartan intervention is more effective than lifestyle intervention.
