The efficacy and safety of recombinant activated factor Ⅶ on uncontrolled perioperative hemorrhage in elderly patients
10.3760/cma.j.issn.0254-9026.2020.07.015
- VernacularTitle:重组活化人凝血因子Ⅶ在老年人围术期大出血中的疗效与安全性
- Author:
Yalin LIU
1
;
Zhigang CHANG
;
Xin CHU
;
Qing HE
;
Zhe FENG
;
Shiyou XIAO
;
Xiaoyu YAN
Author Information
1. 北京医院外科ICU 国家老年医学中心 中国医学科学院老年医学研究院 100730
- From:
Chinese Journal of Geriatrics
2020;39(7):796-799
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the efficacy and safety of recombinant activated factor Ⅶ(rFⅦa)on uncontrolled perioperative hemorrhage in elderly patients in surgical intensive care unit(SICU).Methods:Clinical data of 27 elderly patients with uncontrolled perioperative hemorrhage treated successfully with rFⅦa in surgery-ICU of our hospital from May 2004 to December 2018 were retrospectively analyzed.And the application method and experience were summarized.Results:Of the 27 patients, 16 cases were cured, 11 cases died, and the total fatality rate was 40.74%(11/27). The bleeding stopped in 23 cases, four cases died of uncontrolled peri-operative hemorrhage, and the hemorrhage-caused fatality rate was 14.81%(4/27). Seven patients died of primary diseases after the control of bleeding, with a fatality rate of 25.93%(7/27 ). The thrombin time(TT), prothrombin time(PT), activated partial thromboplastin time(APTT)and international normalized ratio(INR)were reduced and the prothrombin activity(AT)was increased after versus before the application of rFⅦa( Z=-2.197, -3.180, -2.271, -2.803 and 2.756, P=0.028, 0.001, 0.023, 0.005 and 0.006, respectively). Conclusions:rFⅦa has a better effect on uncontrolled peri-operative hemorrhage in elderly patients, when traditional treatments are ineffective.
