Correlation between serum lipoprotein(a)and parameters for left ventricular structure in elderly hypertensive patients
10.3760/cma.j.issn.0254-9026.2020.06.008
- VernacularTitle:老年高血压患者血清脂蛋白(a)与左心结构参数的相关性分析
- Author:
Changlei ZHANG
1
;
Yan WANG
;
Xiaofeng ZHAN
;
Qiuyan WANG
;
Yifang GUO
Author Information
1. 河北医科大学心血管教研室，石家庄 050017；河北省人民医院老年心内科，石家庄 050051
- From:
Chinese Journal of Geriatrics
2020;39(6):639-643
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between lipoprotein(a)[Lp(a)]levels and parameters for left ventricular structure in elderly hypertensive patients.Methods:A total of 65 patients aged ≥65 years diagnosed with essential hypertension were enrolled in this retrospective analysis.Left atrial diameter dilation(LAD)was measured to evaluate the degree of cardiac involvement.According to the existence of LAD, patients were divided into the negative group(n=43)and the positive group(n=22). The differences in levels of blood lipids including Lp(a)and LAD as well as other echocardiographic indexes between the two groups were compared, and their correlations were analyzed.Results:Compared with the negative group, the duration of hypertension, LAD, and Lp(a)level increased in the positive group( P<0.05). LAD was correlated with age, duration of hypertension, left ventricular end diastolic diameter and Lp(a)level.The Lp(a)level was correlated with age and LAD( P<0.05). Logistic regression analysis showed that duration of hypertension( OR=1.060, 95% CI: 1.008-1.116)and Lp(a)level( OR=6.394, 95% CI: 1.038-39.396)were independent risk factors for LAD.The area under the receiver operating characteristic(ROC)curve of Lp(a)for LAD was 0.665(0.524, 0.806). Conclusions:Laboratory testing for serum lipoprotein(a) levels will help assess the degree of cardiac involvement in patients with hypertension and has practical value for the risk assessment of cardiac remodeling in elderly hypertensive patients.
