Safety and efficacy of sacral neuromodulation therapy for lower urinary tract dysfunction in elderly people: A multicenter study
10.3760/cma.j.issn.0254-9026.2020.04.012
- VernacularTitle:骶神经植入术治疗老年人下尿路功能障碍的多中心研究
- Author:
Xiaodong LIU
1
;
Jiawen WANG
;
Lingfeng MENG
;
Wei ZHANG
;
Guanghui DU
;
Qing LING
;
Xiaodong ZHANG
;
Peng ZHANG
;
Zhongqing WEI
;
Baixin SHEN
;
Limin LIAO
;
Guoqing CHEN
;
Hong SHEN
;
Deyi LUO
;
Zhihui XU
;
Jianwei LYU
;
Jiayi LI
;
Tie ZHONG
;
Qi CHEN
;
Wei WEN
;
Yaoguang ZHANG
Author Information
1. 北京医院泌尿外科 国家老年医学中心 100730
- From:
Chinese Journal of Geriatrics
2020;39(4):418-423
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the safety and efficacy of sacral neuromodulation(SNM)therapy for the treatment of lower urinary tract dysfunction(LUTD)in elderly patients.Methods:Clinical data of 91 elderly patients with LUTD from multiple medical institutions who received SNM during the period from January 2012 to December 2016 were retrospectively analyzed.Patients were divided into four groups: the interstitial cystitis(IC)group(n=28), the neurogenic bladder(NB)group(n=36), the overactive bladder syndrome(OAB)group(n=13)and the idiopathic dysuria(ID)group(n=14). Different sets of evaluation parameters were used for different diseases.Patients’ baseline data and data in stage I(test phase)and stage Ⅱ(permanent SNM)were recorded, statistically analyzed and compared.Results:Ninety-one people underwent SNM treatment.Of them, 53 patients received permanent implants(stage Ⅱ), and the total conversion rate of stage I to stage Ⅱ was 58.2%(53/91). Patients receiving permanent implants(stage Ⅱ)had a preoperative period ranging from 3 months to 30 years, and were followed up for 2 to 58 months after treatment, with an average follow-up of 19.6 months.The improvement rates in stage I for urinary urgency, daily urination frequency, daily nocturnal urination frequency, maximum urine volume, daily average urine volume, daily urine leakage frequency, and quality of life score were 35.4%, 31.6%, 33.7%, 32.6%, 49.2%, 43.2% and 13.2%, respectively.The improvement rates in stage Ⅱ for urinary urgency, daily urination frequency, daily nocturnal urination frequency, maximum urine volume, daily average urine volume, daily urine leakage frequency, and quality of life score were 43.2%, 40.0%, 37.8%, 50.5%, 70.5%, 70.4% and 43.2%, respectively.Three adverse events occurred, including 1 case of recurrent symptoms, 1 case of moderate infection, and 1 case of electrical lead dislocation.Conclusions:Sacral nerve stimulation has definitive and consistent curative effects on LUTD in elderly people.The follow-up time should be extended to further study the safety of sacral nerve stimulation.
